综述丨中拉绿色合作为全球气候治理作出“南方贡献”|国产男女无遮挡猛进猛出

###sailaixibu：yizhongfeizaitikangyanyaodetanmisailaixibu（Celecoxib）shiyizhongguangfanyingyongyulinchuangdefeizaitikangyanyao（NSAID），tazhuyaoyongyuhuanjietengtong、jianqingyanzhengyijizhiliaoguanjieyandengjibing。zuoweixuanzexinghuanyanghuamei-2（COX-2）yizhiji，sailaixibuzaimubiaomingquedetongshi，jiaochuantongdeNSAIDxianshichugengdideweichangdaofuzuoyongfengxian。sailaixibudezhuyaozuoyongjizhishiyizhihuanyanghuamei-2dehuoxing，zheyimeizaiyanzhengfanyingzhongqizhezhongyaozuoyong。yuchuantongdeNSAIDbutong，houzhewangwangtongshiyizhiCOX-1heCOX-2，kenengdaozhiweichangdaobushi、kuiyangdengbuliangfanying。sailaixibudexuanzexingyizhishiqizaitigongkangyanhezhentongxiaoguodetongshi，gengjiawenhediduidaiweichangdao。linchuangshang，sailaixibuchangchangyongyuzhiliaofengshixingguanjieyan、guguanjieyanjijixingtengtongdeng。ciwai，tahaibeiyongyutongjingjiqitaleixingdemanxingtengtongzhuangkuang。yanjiubiaoming，sailaixibunenggouyouxiaokongzhizhengzhuang，tigaohuanzheshenghuozhiliang。jinguansailaixibuxiangduianquan，danzaishiyongshiyiranxuyaozhuyiyixiefuzuoyong，youqishixinxueguanfengxian。bufenyanjiuxianshi，changqidajiliangshiyongkenengzengjiaxinzangbingfazuohezhongfengdefengxian。yinci，yishengzaikaichufangshiyibanhuizonghekaolvhuanzhedezhengtijiankangzhuangkuang，zhidinggexinghuadeyongyaofangan。zongzhi，sailaixibuzuoweiyizhongxiandaiyaowu，pingjieqidutedejizhihexiangduianquande#(#)#(#)#(#)塞(sai)来(lai)昔(xi)布(bu)：(：)一(yi)种(zhong)非(fei)甾(zai)体(ti)抗(kang)炎(yan)药(yao)的(de)探(tan)秘(mi)塞(sai)来(lai)昔(xi)布(bu)（(（)C(C)e(e)l(l)e(e)c(c)o(o)x(x)i(i)b(b)）(）)是(shi)一(yi)种(zhong)广(guang)泛(fan)应(ying)用(yong)于(yu)临(lin)床(chuang)的(de)非(fei)甾(zai)体(ti)抗(kang)炎(yan)药(yao)（(（)N(N)S(S)A(A)I(I)D(D)）(）)，(，)它(ta)主(zhu)要(yao)用(yong)于(yu)缓(huan)解(jie)疼(teng)痛(tong)、(、)减(jian)轻(qing)炎(yan)症(zheng)以(yi)及(ji)治(zhi)疗(liao)关(guan)节(jie)炎(yan)等(deng)疾(ji)病(bing)。(。)作(zuo)为(wei)选(xuan)择(ze)性(xing)环(huan)氧(yang)化(hua)酶(mei)-(-)2(2)（(（)C(C)O(O)X(X)-(-)2(2)）(）)抑(yi)制(zhi)剂(ji)，(，)塞(sai)来(lai)昔(xi)布(bu)在(zai)目(mu)标(biao)明(ming)确(que)的(de)同(tong)时(shi)，(，)较(jiao)传(chuan)统(tong)的(de)N(N)S(S)A(A)I(I)D(D)显(xian)示(shi)出(chu)更(geng)低(di)的(de)胃(wei)肠(chang)道(dao)副(fu)作(zuo)用(yong)风(feng)险(xian)。(。)塞(sai)来(lai)昔(xi)布(bu)的(de)主(zhu)要(yao)作(zuo)用(yong)机(ji)制(zhi)是(shi)抑(yi)制(zhi)环(huan)氧(yang)化(hua)酶(mei)-(-)2(2)的(de)活(huo)性(xing)，(，)这(zhe)一(yi)酶(mei)在(zai)炎(yan)症(zheng)反(fan)应(ying)中(zhong)起(qi)着(zhe)重(zhong)要(yao)作(zuo)用(yong)。(。)与(yu)传(chuan)统(tong)的(de)N(N)S(S)A(A)I(I)D(D)不(bu)同(tong)，(，)后(hou)者(zhe)往(wang)往(wang)同(tong)时(shi)抑(yi)制(zhi)C(C)O(O)X(X)-(-)1(1)和(he)C(C)O(O)X(X)-(-)2(2)，(，)可(ke)能(neng)导(dao)致(zhi)胃(wei)肠(chang)道(dao)不(bu)适(shi)、(、)溃(kui)疡(yang)等(deng)不(bu)良(liang)反(fan)应(ying)。(。)塞(sai)来(lai)昔(xi)布(bu)的(de)选(xuan)择(ze)性(xing)抑(yi)制(zhi)使(shi)其(qi)在(zai)提(ti)供(gong)抗(kang)炎(yan)和(he)镇(zhen)痛(tong)效(xiao)果(guo)的(de)同(tong)时(shi)，(，)更(geng)加(jia)温(wen)和(he)地(di)对(dui)待(dai)胃(wei)肠(chang)道(dao)。(。)临(lin)床(chuang)上(shang)，(，)塞(sai)来(lai)昔(xi)布(bu)常(chang)常(chang)用(yong)于(yu)治(zhi)疗(liao)风(feng)湿(shi)性(xing)关(guan)节(jie)炎(yan)、(、)骨(gu)关(guan)节(jie)炎(yan)及(ji)急(ji)性(xing)疼(teng)痛(tong)等(deng)。(。)此(ci)外(wai)，(，)它(ta)还(hai)被(bei)用(yong)于(yu)痛(tong)经(jing)及(ji)其(qi)他(ta)类(lei)型(xing)的(de)慢(man)性(xing)疼(teng)痛(tong)状(zhuang)况(kuang)。(。)研(yan)究(jiu)表(biao)明(ming)，(，)塞(sai)来(lai)昔(xi)布(bu)能(neng)够(gou)有(you)效(xiao)控(kong)制(zhi)症(zheng)状(zhuang)，(，)提(ti)高(gao)患(huan)者(zhe)生(sheng)活(huo)质(zhi)量(liang)。(。)尽(jin)管(guan)塞(sai)来(lai)昔(xi)布(bu)相(xiang)对(dui)安(an)全(quan)，(，)但(dan)在(zai)使(shi)用(yong)时(shi)依(yi)然(ran)需(xu)要(yao)注(zhu)意(yi)一(yi)些(xie)副(fu)作(zuo)用(yong)，(，)尤(you)其(qi)是(shi)心(xin)血(xue)管(guan)风(feng)险(xian)。(。)部(bu)分(fen)研(yan)究(jiu)显(xian)示(shi)，(，)长(chang)期(qi)大(da)剂(ji)量(liang)使(shi)用(yong)可(ke)能(neng)增(zeng)加(jia)心(xin)脏(zang)病(bing)发(fa)作(zuo)和(he)中(zhong)风(feng)的(de)风(feng)险(xian)。(。)因(yin)此(ci)，(，)医(yi)生(sheng)在(zai)开(kai)处(chu)方(fang)时(shi)一(yi)般(ban)会(hui)综(zong)合(he)考(kao)虑(lv)患(huan)者(zhe)的(de)整(zheng)体(ti)健(jian)康(kang)状(zhuang)况(kuang)，(，)制(zhi)定(ding)个(ge)性(xing)化(hua)的(de)用(yong)药(yao)方(fang)案(an)。(。)总(zong)之(zhi)，(，)塞(sai)来(lai)昔(xi)布(bu)作(zuo)为(wei)一(yi)种(zhong)现(xian)代(dai)药(yao)物(wu)，(，)凭(ping)借(jie)其(qi)独(du)特(te)的(de)机(ji)制(zhi)和(he)相(xiang)对(dui)安(an)全(quan)的(de)