肿瘤细胞为何能“免疫逃逸”?最新研究揭示:感觉神经被“劫持”|搡8O老女人老妇人老熟

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  中新网上海10月25日电 (记者 陈静)肿瘤是一种系统性疾病。肿瘤细胞如何利用远隔组织或器官,在全身环境下完成免疫逃逸是专家学者们致力研究的一个课题。记者25日获悉,中国的医学专家和学者最新研究率先揭示免疫压力下的肿瘤细胞实现免疫逃逸的机制,并找到了应对的方法。

  据悉,肿瘤细胞会通过细胞内部、细胞之间、不同组织乃至器官之间等多个层面的复杂机制,躲避人体免疫系统的攻击,这一过程被称为“免疫逃逸”。

  中国专家学者的研究首次发现,免疫压力下的肿瘤细胞,可“劫持”感觉神经,远程抑制引流淋巴结(TDLN)中的系统性抗肿瘤免疫应答,从而实现免疫逃逸。阻断这种神经介导的肿瘤-TDLN通讯不仅可显著增强免疫治疗疗效,也能显著抑制癌痛。

  中国科学院院士樊嘉,复旦大学附属中山医院季彤教授、周俭教授及孙云帆教授团队联合上海交通大学张陈平教授的研究成果在线发表于最新一期国际权威期刊《细胞》(Cell)杂志上。据悉,他们的研究不仅为理解神经调控肿瘤演进的作用提供了宏环境尺度的新视角,也为开发兼具抑瘤与镇痛作用的治疗新策略提供了理论依据与实验支持。

  研究发现肿瘤组织中感觉神经富集,一方面,高感觉神经丰度与患者更强的术前疼痛相关;另一方面,高感觉神经丰度还促进患者肿瘤组织及外周血中的抑制性免疫。经过一系列研究,研究人员发现,使用国内外均已上市的偏头痛治疗药物CGRP受体抑制剂阻断感觉神经介导的肿瘤—TDLN通讯可以显著增强免疫治疗疗效并抑制癌痛,从而实现抑瘤与镇痛的双重作用。(完)

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