天津大学团队研发发热伴血小板减少综合征病毒检测新方法|实拍女处破www免费看

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  中新网天津11月18日电 (记者 孙玲玲)你听说过发热伴血小板减少综合征吗?这是一种由蜱虫传播的病毒引起的传染病,患者会出现高热、血小板下降,严重时还会多器官损伤,重症致死率可达30%。由于没有特效药,也缺少快速检测的办法,它被世界卫生组织列为十大急需关注的传染病之一。所以,能不能早点发现这种病毒,对防控特别关键。

  近日,天津大学医学部生命科学学院、天津大学合成生物技术国家重点实验室的王涛教授团队研究出了一种“时序温控”的检测新方法(TCOD),为发热伴血小板减少综合征病毒的快速诊断提供了高灵敏度、低成本的新方案。研究成果以《一种温控单管CRISPR/Cas12b联合等温扩增技术检测系统在发热伴血小板减少综合征病毒检测中的应用》为题在线发表在国际期刊《传感器与执行器B:化学》(Sensors and Actuators: B. Chemical)上。该工作得到了国家自然科学基金的支持。

  据介绍,该研究把对发热伴血小板减少综合征病毒的扩增与检测“整合”在了一个试管里,通过时序调节温度变化控制检测流程,实现对发热伴血小板减少综合征病毒的灵敏高效识别。

  通过对各种反应参数的系统优化,该研究成果显著提升了检测灵敏度和体系稳定性,整个检测流程仅需45分钟即可获得结果。新检测方法的检测结果还可在蓝光照射下,通过肉眼观察直接区分阳性与阴性样本,展现出优异的现场可操作性和直观可视化特征。

  团队还用52份临床血清样本对该检测方法进行了验证,结果显示该检测方法的检测结果与目前常用的荧光定量检测方法的检测结果完全一致,准确率100%。新检测体系可以采用冻干预混保存策略,稳定性高,运输和储存都很方便,可广泛应用于基层医疗、口岸检疫、疫情应急监测等场景。

  据介绍,该研究成果不仅为发热伴血小板减少综合征病毒的快速检测提供了新思路,也为CRISPR分子诊断平台的温度调控设计提供了新的范式。未来,该体系有望扩展至多种病原体的快速检测与现场监测中,为传染病的早期防控提供重要支撑。(完)

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